Calcium Acetate

Inquiry

Cat Number

API62544

CAS Number

62-54-4

If you have any other questions, please contact our experts.

Product Detail Description Advanced Innovations Customer Q&A

CAS Number

62-54-4

EINECS

200-540-9

Synonyms

Calcium diacetate

Molecular Formula

C4H6CaO4

Molecular Weight

158.17

Smiles

CC(=O)[O-].CC(=O)[O-].[Ca+2]

Appearance

White powder

Melting Point

160°C℃

Relative Density

1.5

General Description

Calcium Acetate is an organic calcium salt serving dual functions as a phosphate binder and calcium supplement. It is highly effective in controlling serum phosphorus levels in renal failure.

Mechanism of Action

Calcium Acetate dissociates in the intestine, where calcium ions bind dietary phosphate to form insoluble calcium phosphate that is excreted in feces. This reduces phosphorus absorption while simultaneously supplementing calcium.

Application

Used in the management of hyperphosphatemia. Calcium Acetate is indicated for serum phosphorus control in patients with end-stage renal disease on dialysis, and for hypocalcemia associated with chronic kidney disease.

A novel compound effervescent granule of calcium acetate was developed using wet granulation method with citric acid and sodium bicarbonate as effervescent base, optimized by orthogonal experiment. The formulation consisted of calcium acetate, citric acid, sodium bicarbonate, PEG6000, aspartame, PVP ethanol solution, lactose and vitamin D. The granules were evaluated for particle size, repose angle, pH value, calcium acetate content and effervescence time. In vivo studies demonstrated that the effervescent granules exhibited prominent bone-mass loss prevention and superior bone microarchitecture enhancement compared to other calcium preparations in Micro-CT analysis. This novel dosage form offers a promising approach for calcium supplementation with improved palatability and therapeutic efficacy.

References

Liu Z, et al. Preparation and Characterization of the Biological Compound Effervescent Granule of Calcium Acetate. Current Pharmaceutical Biotechnology, 2019, 20(11): 934-944.

What advantage does Calcium Acetate offer over calcium carbonate as a phosphate binder?

Calcium Acetate is more effective per gram of elemental calcium, providing superior phosphate binding at lower calcium loads, reducing the risk of hypercalcemia.

What is the minimum order quantity (MOQ)?

Flexible MOQ options are available to support both early-stage research and large-scale manufacturing needs.

What purity grade is available?

It is supplied as a high-purity grade suitable for R&D and pharmaceutical manufacturing.

Can packaging and order quantities be customized?

Yes, both packaging formats and order quantities can be tailored to meet specific R&D and production needs.