Boc-N-Me-Val-OH

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Cat Number

INT45170318

CAS Number

45170-31-8

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Product Detail Description Customer Q&A

CAS Number

45170-31-8

Storage

Store at room temperature

Synonyms

BOC-N-METHYL-L-VAL-OH;Boc-N-me-Val;N-ALPHA-TERT-BUTYLOXYCABONYL-N-ALPHA-METHYL-L-VALINE;NALPHA-tert-Butoxycarbonyl-N-methyl-L-valine

Molecular Formula

C11H21NO4

Molecular Weight

231.29

Smiles

C(O)(=O)[C@H](C(C)C)N(C(OC(C)(C)C)=O)C

Appearance

Off-white solid

Melting Point

45-60℃

Boiling Point

322.4℃

Relative Density

1.069

pKa

4.03

General Description

Boc-N-Me-Val-OH is an N-methylated version of L-valine featuring a tert-butoxycarbonyl protecting group. N-methylation of the amide nitrogen is a key modification used to improve the drug-like properties of peptide sequences.

Mechanism of Action

It introduces a methyl group onto the peptide backbone nitrogen, which removes the hydrogen-bond donor ability of that amide. This results in altered peptide folding, increased lipophilicity, and significantly enhanced resistance to cleavage by proteolytic enzymes.

Application

It is a vital component in the synthesis of cyclic peptides and peptidomimetics aimed at improving oral bioavailability and metabolic half-life in therapeutic development.