Betamethasone Benzoate

Inquiry

Cat Number

API22298299

CAS Number

22298-29-9

If you have any other questions, please contact our experts.

Product Detail Description Customer Q&A

CAS Number

22298-29-9

Storage

2-8℃

Molecular Formula

C29H33FO6

Molecular Weight

496.6

Smiles

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)OC(=O)C5=CC=CC=C5)C)O)F)C

Appearance

Powder

General Description

Betamethasone Benzoate is a synthetic corticosteroid ester combining betamethasone with benzoic acid, designed for enhanced topical bioavailability and penetration into the skin. The benzoate ester increases lipophilicity compared to the base betamethasone molecule, facilitating more efficient delivery across the stratum corneum. It is classified as a high-potency topical corticosteroid.

Mechanism of Action

Betamethasone Benzoate acts through glucocorticoid receptor (GR)-mediated modulation of gene transcription, inducing the synthesis of lipocortin-1 (annexin-1), which inhibits phospholipase A2 and thereby reduces the formation of arachidonic acid derivatives including prostaglandins and leukotrienes. It also suppresses the migration of polymorphonuclear leukocytes, reduces capillary permeability, and exerts antiproliferative effects on fibroblasts, collectively attenuating the inflammatory cascade in skin.

Application

Betamethasone Benzoate is indicated for the topical treatment of corticosteroid-responsive dermatoses including atopic dermatitis, contact dermatitis, psoriasis, seborrheic dermatitis, and lichen planus where high-potency anti-inflammatory action is required.

What is the recommended storage condition for Betamethasone Benzoate?

It should be stored at 2-8°C in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Can we obtain batch-specific analytical data for Betamethasone Benzoate?

Batch-specific COA documents are standard with every shipment. Additional analytical reports, including HPLC chromatograms or spectral data, may be provided upon request.

What is the minimum order quantity (MOQ) for Betamethasone Benzoate?

Flexible MOQ options are available to support both early-stage research and large-scale manufacturing needs. Our team can tailor order quantities to match your specific requirements.

Is Betamethasone Benzoate available in micronized form?

Micronized grades with controlled particle size distribution are available for topical or inhalation formulation applications. Please contact us with specific particle size requirements.