Bepridil Hydrochloride

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Cat Number

API68099865

CAS Number

68099-86-5

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Product Detail Description Scientific Support Customer Q&A

CAS Number

68099-86-5

EINECS

268-472-2

Storage

Store at room temperature

Synonyms

Bepridil HCl; Angopril; 1978CERM; UNII-2TN7FF3W4M; Bepridil hydrochloride anhydrous

Molecular Formula

C24H35ClN2O

Molecular Weight

403

Smiles

CC(C)COCC(CN(CC1=CC=CC=C1)C2=CC=CC=C2)N3CCCC3.Cl

Appearance

White to light yellow solid powder

Boiling Point

492.3°C at 760 mmHg

Relative Density

1.054

General Description

Bepridil hydrochloride is a calcium channel blocker with a unique diphenylalkylamine structure, containing a pyrrolidine ring and a phenyl group. Its chemical structure is N‑(2‑ethylamino)‑3‑(3‑isobutoxy‑2‑pyrrolidinyl)‑2‑methylpropanamide hydrochloride.

Mechanism of Action

Bepridil acts as a calcium channel blocker with additional class I antiarrhythmic properties, inhibiting both calcium and sodium channels in cardiac and vascular tissues. It reduces heart rate and myocardial contractility, decreases peripheral vascular resistance, and prolongs the action potential duration. The drug also has a mild local anesthetic effect.

Application

Bepridil was indicated for the treatment of chronic stable angina and for the management of supraventricular and ventricular arrhythmias.

In 76 patients with persistent atrial fibrillation, response to bepridil (≤200 mg/day) before ablation was associated with a lower low-voltage zone (LVZ) ratio (7.5% vs 14.0%, P=0.009) and higher 1-year recurrence-free survival after ablation (87.1% vs 62.3%, P=0.03). Response to bepridil is a marker of normal atrial voltage and predicts better outcomes after catheter ablation.

Fig. 1 Recurrence‐free rates after catheter ablation. (Yakabe D, et al., 2021)

References

Yakabe D, et al. Responsiveness to bepridil predicts atrial substrate in patients with persistent atrial fibrillation. J Arrhythm. 2021;37(1):79-87.

Does Bepridil Hydrochloride require protection from light during storage?

Yes, it is photosensitive. UV exposure can cause photodegradation and discoloration. Store in light-resistant containers, preferably amber glass.

What is the recommended storage temperature for Bepridil Hydrochloride?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which can accelerate oxidation of the pyrrolidine ring.

Is Bepridil Hydrochloride hygroscopic, and how is this managed?

It is slightly hygroscopic. Under high humidity (>70% RH), it may absorb moisture and clump. Storage in tightly sealed containers with desiccant is recommended.