Azetidine hydrochloride

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Cat Number

INT36520395

CAS Number

36520-39-5

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Product Detail Description Customer Q&A

CAS Number

36520-39-5

EINECS

627-415-5

Storage

2-8℃

Synonyms

Trimethylene imine hydrochloride, 1,3-Propylenimine hydrochloride, Azacyclobutane hydrochloride;azetadine hydrochloride

Molecular Formula

C3H8ClN

Molecular Weight

93.55

Smiles

C1CNC1.Cl

Appearance

White to off-white powder

Melting Point

>300℃

General Description

Azetidine Hydrochloride is the hydrochloride salt of azetidine, a four-membered saturated nitrogen-containing heterocycle (pyrrolidine's one-ring smaller analog). The hydrochloride salt is a stable, free-flowing crystalline solid that is freely soluble in water and polar organic solvents. Azetidine is the simplest saturated nitrogen heterocycle larger than aziridine (three-membered), and its constrained geometry makes it valuable in medicinal chemistry.

Mechanism of Action

Azetidine Hydrochloride functions as a constrained amine building block and as a pharmacophore in its own right. The four-membered ring constrains the N-C-C-C torsion angles, restricting the conformational space accessible to molecules incorporating the azetidine ring compared to piperidine or pyrrolidine. This conformational restriction can improve target selectivity, reduce off-target binding, and increase metabolic stability by blocking oxidation at the ring carbons.

Application

Azetidine Hydrochloride is used as an intermediate in the synthesis of pharmaceuticals, particularly those targeting the nervous system, where constrained amines are valued for their selectivity and metabolic stability. The azetidine ring is found in several clinical candidates for the treatment of Parkinson's disease, depression, and pain. It is also used as a precursor for chiral auxiliaries, protecting groups, and as a building block in polymer chemistry.

What is the recommended storage condition for Azetidine hydrochloride?

It should be stored at 2-8°C in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Is a Certificate of Analysis (COA) available for Azetidine hydrochloride?

Yes, a fully verified COA is issued for every batch and can be shared electronically. Additional documentation such as MSDS or impurity profiles may be requested separately.

What analytical characterization data is available for Azetidine hydrochloride?

Standard analytical data including HPLC purity profile, NMR confirmation, and physical specifications are included in the COA. Additional characterization data can be arranged upon request.

What functional groups in Azetidine hydrochloride are available for further chemical modification?

The specific reactive handles present in this intermediate can be confirmed by reviewing the technical data sheet. Our team can provide structural and reactivity information relevant to your synthetic route.

What quality standards govern the production of Azetidine hydrochloride?

Production is carried out under GMP-aligned quality systems with full traceability and documented quality controls for each manufacturing run.