Anileridine Phosphate

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Cat Number

API1976756

CAS Number

1976-75-6

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CAS Number

1976-75-6

Synonyms

4-Piperidinecarboxylic acid, 1-(2-(4-aminophenyl)ethyl)-4-phenyl-, ethyl ester, phosphate (1:1)

Molecular Formula

C22H31N2O6P

Molecular Weight

450.5

Smiles

CCOC(=O)C1(CCN(CC1)CCC2=CC=C(C=C2)N)C3=CC=CC=C3.OP(=O)(O)O

General Description

Anileridine Phosphate is the phosphate salt of anileridine, a synthetic opioid analgesic of the 4-phenylpiperidine class and a structural analog of pethidine (meperidine). It features a p-aminophenyl group substitution on the piperidine ring nitrogen that distinguishes it from meperidine.

Mechanism of Action

Anileridine Phosphate acts as a full agonist at mu-opioid receptors (MOR), activating inhibitory Gi/o proteins to reduce neuronal excitability. It suppresses neuronal firing, decreases cAMP levels, and modulates ion channel conductance in pain-processing pathways of the central nervous system.

Application

Indicated for the management of moderate to severe pain. Anileridine Phosphate is a synthetic 4-phenylpiperidine opioid analgesic and a structural analog of meperidine, providing analgesia through mu-opioid receptor agonism with a p-aminophenyl substitution that confers distinct receptor affinity and metabolic profiles.

What distinguishes Anileridine from Meperidine?

Anileridine contains a p-aminophenyl group on the piperidine nitrogen instead of the N-methyl group in meperidine, conferring different receptor affinity and metabolic profiles.