General Description
Amphetamine Adipate is the adipate salt of amphetamine, a potent central nervous system stimulant of the amphetamine class. The adipate salt offers improved chemical stability and is used in controlled-release oral formulations. Amphetamine acts as a substrate for monoamine neurotransmitter transporters, increasing the synaptic concentrations of dopamine, norepinephrine, and, to a lesser extent, serotonin in the brain.
Mechanism of Action
Amphetamine Adipate functions as a substrate-type releaser and reuptake inhibitor at vesicular monoamine transporter 2 (VMAT2), dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT). By displacing monoamines from vesicular storage, inhibiting their reuptake, and reversing transporter flux, it dramatically increases extracellular concentrations of dopamine and norepinephrine, particularly in the prefrontal cortex and striatum, producing pronounced stimulant effects on attention, arousal, and reward processing.
Application
Amphetamine Adipate is indicated for the treatment of attention deficit hyperactivity disorder (ADHD) in children, adolescents, and adults, and for the treatment of narcolepsy.