Aminohippurate Sodium

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Cat Number

API0231645

CAS Number

94-16-6

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Product Detail Description Customer Q&A

CAS Number

94-16-6

EINECS

202-309-8

Storage

Store at room temperature

Synonyms

Sodium p-aminohippurate; p-Aminohippurate sodium; Monosodium p-aminohippurate; Natrium 4-aminohippurat; Sodium para-Aminohippurate

Molecular Formula

C9H9N2NaO3

Molecular Weight

216.17

Smiles

C1=CC(=CC=C1C(=O)NCC(=O)[O-])N.[Na+]

Appearance

White to off-white crystalline powder

General Description

Aminohippurate sodium (para-aminohippurate or PAH) is an organic anion used to measure effective renal plasma flow (ERPF) and to assess tubular secretion function. It is administered intravenously as a continuous infusion or as a bolus. The drug is also known as PAH and has been a classic renal physiology tool for decades.

Mechanism of Action

PAH is freely filtered at the glomerulus and actively secreted into the proximal tubule by the organic anion transporter (OAT) system. At low plasma concentrations, nearly all PAH delivered to the kidney is excreted, such that its clearance approximates total renal plasma flow. The extraction ratio of PAH in healthy kidneys is about 90%, making it the gold standard for ERPF measurement.

Application

Aminohippurate sodium is used to calculate renal plasma flow and to estimate tubular secretory capacity. It is also employed to differentiate between prerenal azotemia and intrinsic renal disease by measuring fractional excretion of PAH.

Does Aminohippurate Sodium require protection from light during storage?

Yes, it is photosensitive. Light exposure can cause discoloration and degradation of the hippurate moiety. Store in light-resistant containers.

What is the recommended storage temperature for Aminohippurate Sodium?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which accelerates hydrolysis to 4-aminobenzoate and hippuric acid.

Is Aminohippurate Sodium stable in solution for diagnostic renal function tests?

Solutions are stable for 24 hours at room temperature when protected from light. We provide in-use stability data for various concentrations and preservatives.

How is the impurity 4-aminobenzoic acid (PABA) monitored during stability?

This primary hydrolysis product is specifically quantified using a stability-indicating HPLC method, ensuring it remains within acceptable limits.