AfatinibBIBW 2992, Afatinib free base

AfatinibBIBW 2992, Afatinib free base

Cat Number
API850140726
CAS Number
850140-72-6

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CAS Number
850140-72-6
Storage
Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.
Description
Afatinib (BIBW 2992) is an irreversible inhibitor of the EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M, and HER2) with IC50s of 0.5 nM, 0.4 nM, 10 nM, and 14 nM, respectively.
Molecular Formula
C24H25ClFN5O3
Molecular Weight
485.94
Smiles
N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4
Relative Density
1.38
Purity
0.999
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