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AfatinibBIBW 2992, Afatinib free base

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Cat Number

API850140726

CAS Number

850140-72-6

For research use only. We do not supply to patients.

For pharmaceutical-grade products or other inquiries, please contact our experts.

Product Detail

CAS Number

850140-72-6

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Description

Afatinib (BIBW 2992) is an irreversible inhibitor of the EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M, and HER2) with IC50s of 0.5 nM, 0.4 nM, 10 nM, and 14 nM, respectively.

Molecular Formula

C24H25ClFN5O3

Molecular Weight

485.94

Smiles

N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

Relative Density

1.38

Purity

0.999

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All our products are chemicals for research purposes only. We do not supply for human or veterinary applications.