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(S)-Afatinib

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Cat Number

API439081182

CAS Number

439081-18-2

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Product Detail

CAS Number

439081-18-2

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Description

(S)-Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, EGFR (L858R), EGFR (L858R/T790M), HER2, and HER4, respectively.

Molecular Formula

C24H25ClFN5O3

Molecular Weight

485.94

Smiles

CN(C)CC=CC(=O)NC1CC2C(NC3CCC(F)C(Cl)C3)NCNC2CC1O[C@H]1CCOC1

Relative Density

1.38

Purity

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