Ademetionine Disulfatetosylate

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Cat Number

API97540222

CAS Number

97540-22-2

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Product Detail Description Customer Q&A

CAS Number

97540-22-2

EINECS

249-946-8

Storage

Store at 2-8°C

Synonyms

S-Adenosyl-L-Methionine disulfate tosylate(SAM-T); S-adenisyl-L-Methioninedisulfate-p-toluenesulfonate; SAM-T; S-Adenosyl-L-Methionine Disulfate p-Toluenesulfonate

Molecular Formula

C22H34N6O16S4

Molecular Weight

766.79

Smiles

S(C1C=CC(C)=CC=1)(O)(=O)=O.S(O)(O)(=O)=O.O[C@@H]1[C@@H]([C@@H](C[S+](C)CC[C@H](N)C(=O)O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O.S(O)([O-])(=O)=O

Appearance

White to off-white crystalline powder

Melting Point

195-205°C (dec.)

Relative Density

1.35±0.1

General Description

Ademetionine disulfatetosylate is another stable salt form of S-adenosylmethionine (SAMe). It is a metabolite that binds the sulfur-containing amino acid methionine to adenosine triphosphate. This salt form serves as a ubiquitous methyl donor, and is available as the disulfate tosylate form.

Mechanism of Action

As a methyl donor and cofactor, Ademetionine disulfatetosylate is involved in a variety of biological processes, including epigenetic regulation (DNA and protein methylation) and the post-translational modification of proteins. It promotes the synthesis of phosphatidylcholine, which is important for cell membrane integrity. The compound's role in methylation is critical for the synthesis of various molecules, including neurotransmitters, hormones, and proteins.

Application

Ademetionine disulfatetosylate is used as a dietary supplement and pharmaceutical ingredient. It has been explored in clinical settings for its potential benefits in treating liver diseases, depression, and osteoarthritis. It is reported to have potent antidepressant effects, and as an anti-inflammatory agent, it is used in the management of chronic liver diseases. It is also being investigated for its anti-proliferative, pro-apoptotic, and anti-metastatic effects in cancer.

Does Ademetionine Disulfatetosylate require protection from light and heat during storage?

Yes, it is sensitive to both. Light accelerates photodegradation; heat promotes decomposition of the sulfonium center. Store at 2-8°C in light-resistant containers.

Is Ademetionine Disulfatetosylate more stable than other ademetionine salts?

The disulfatetosylate salt form offers enhanced thermal stability compared to the tosylate alone, but refrigeration is still recommended for long-term storage.

What packaging is recommended for long-term storage of Ademetionine Disulfatetosylate?

Use amber glass bottles with desiccant, sealed under nitrogen, and stored at 2-8°C. Avoid plastic containers that may absorb moisture.

How is the impurity S-adenosyl-L-homocysteine (SAH, a de-methylation product) monitored?

SAH is quantified using a stability-indicating HPLC method, ensuring it remains within pharmacopoeial or in-house specifications.