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8-hydroxy Efavirenz

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Cat Number

API205754332

CAS Number

205754-33-2

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Product Detail

CAS Number

205754-33-2

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Description

8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz . 8-hydroxy Efavirenz is formed when efavirenz is metabolized by the cytochrome P450 (CYP) isoform CYP2B6. It induces apoptosis in rat primary hippocampal neurons and loss of dendritic spines in rat primary hippocampal neuronal cultures when used at a concentration of 0.01 μM.

Molecular Formula

C14H9ClF3NO3

Molecular Weight

331.68

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