6-bromo-2-(difluoromethyl)-3-fluoropyridine

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Cat Number

INT1806763563

CAS Number

1806763-56-3

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Product Detail Description Customer Q&A

CAS Number

1806763-56-3

Storage

2-8℃

Molecular Formula

C6H3BrF3N

Molecular Weight

225.99

Smiles

C1=CC(=NC(=C1F)C(F)F)Br

Appearance

White to off-white solid

Boiling Point

189.3℃

Relative Density

1.725

General Description

6-bromo-2-(difluoromethyl)-3-fluoropyridine is an electron-deficient, poly-halogenated pyridine derivative. It features a bromine atom at the 6-position, a fluorine atom at the 3-position, and a difluoromethyl group at the 2-position. This unique combination of substituents creates a highly functionalized aromatic core suitable for diverse synthetic transformations.

Mechanism of Action

It serves as a versatile aryl building block in transition-metal catalyzed reactions. The presence of multiple halogen atoms and a difluoromethyl group allows for site-selective cross-coupling reactions (such as Suzuki, Buchwald, or Stille) to build complex poly-substituted pyridine systems with tuned electronic properties.

Application

It is extensively utilized as a key intermediate in the discovery and synthesis of novel pharmaceutical inhibitors and agrochemical agents where specific lipophilicity and electronic modulation are necessary.