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5-isothiocyanato-3-(trifluoromethyl)picolinonitrile

5-isothiocyanato-3-(trifluoromethyl)picolinonitrile

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Cat Number
INT951753870
CAS Number
951753-87-0

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CAS Number
951753-87-0
Synonyms
2-Pyridinecarbonitrile, 5-isothiocyanato-3-(trifluoromethyl)-
Molecular Formula
C8H2F3N3S
Molecular Weight
229.18
Smiles
C1(C#N)=NC=C(N=C=S)C=C1C(F)(F)F
Appearance
White to off-white solid
Boiling Point
367.7℃
Relative Density
1.41
General Description
5-isothiocyanato-3-(trifluoromethyl)picolinonitrile is a highly functionalized pyridine derivative containing an isothiocyanate group, a trifluoromethyl group, and a nitrile group. It is an extremely reactive electrophile.
Mechanism of Action
It functions as an activated building block for heterocycle synthesis. The isothiocyanate group reacts readily with amines to form thiourea linkages, while the nitrile and trifluoromethyl groups modulate the electronics of the pyridine ring for specific targeting.
Application
It is a critical intermediate for the synthesis of second-generation androgen receptor antagonists, such as Enzalutamide and Apalutamide, used in oncology.

Is 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile reactive?

Yes, it is a highly reactive electrophile that must be handled with care.

What is the main application of 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile?

It is used to synthesize oncology drugs like Enzalutamide.

How to store 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile?

It should be kept under an inert atmosphere in a cool, dry place.

Does 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile meet international standards?

Yes, it is manufactured according to high international industry standards.

Are COAs provided for 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile?

Yes, a batch-specific COA is provided with it for every shipment.

Is global shipping available for 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile?

Yes, we offer global logistics for it in specialized packaging.
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