4,5-Dimethyl-1H-imidazole hydrochloride

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Cat Number

INT53316511

CAS Number

53316-51-1

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Product Detail Description Customer Q&A

CAS Number

53316-51-1

Storage

2-8℃

Synonyms

4,5-dimethyl-1H-imidazole hydrogen chloride

Molecular Formula

C5H9ClN2

Molecular Weight

132.59

Smiles

C1(C)=C(C)NC=N1.Cl

Appearance

Off-white solid

Melting Point

305℃

General Description

4,5-Dimethyl-1H-imidazole hydrochloride is the salt form of a substituted imidazole bearing methyl groups at the C-4 and C-5 positions of the five-membered heterocyclic ring. The imidazole ring contains two nitrogen atoms (N-1 and N-3), and the C-4/C-5 methyl substituents enhance lipophilicity and steric bulk at the unsubstituted carbon positions.

Mechanism of Action

4,5-Dimethyl-1H-imidazole functions as a protected and stabilized imidazole building block in pharmaceutical synthesis. The methyl groups at C-4 and C-5 block these positions from electrophilic substitution and oxidation, providing regioselectivity in further functionalization at the C-2 position (where the N-H is located) and at the nitrogen atoms. The imidazole core is a key structural motif in many receptor ligands and enzyme inhibitors.

Application

4,5-Dimethyl-1H-imidazole hydrochloride is used as an intermediate in the synthesis of imidazole-containing pharmaceuticals including the antihypertensive agent clonidine (via 2-substitution), the fungicide ketoconazole analogs, and histamine H3 receptor ligands. The 4,5-dimethyl substitution pattern is found in several CNS drug candidates targeting GPCRs and ion channels. It is also used as a catalyst and precursor for N-heterocyclic carbene (NHC) ligands.

What is the recommended storage condition for 4,5-Dimethyl-1H-imidazole hydrochloride?

It should be stored at 2-8°C in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

What documentation is provided with each batch of 4,5-Dimethyl-1H-imidazole hydrochloride?

Each batch is accompanied by a Certificate of Analysis (COA) covering identity, potency, and relevant purity tests. Safety Data Sheets (SDS) are available upon request.

Is 4,5-Dimethyl-1H-imidazole hydrochloride compatible with common organic solvents used in pharmaceutical synthesis?

Solubility and compatibility information is available in the technical data sheet. For specific solvent compatibility questions, please contact our technical team.

Can 4,5-Dimethyl-1H-imidazole hydrochloride be provided with custom specifications for synthetic applications?

Custom specifications including adjusted particle size, solvent residue limits, or additional purity testing can be arranged for qualified customers with defined requirements.

What quality standards govern the production of 4,5-Dimethyl-1H-imidazole hydrochloride?

Production is carried out under GMP-aligned quality systems with full traceability and documented quality controls for each manufacturing run.