4-Pyridinebutane-1-ol

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Cat Number

INT5264153

CAS Number

5264-15-3

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Product Detail Description Customer Q&A

CAS Number

5264-15-3

EINECS

231-810-4

Storage

Room temperature

Synonyms

4-(4-Pyridinyl)-1-butanol;4-Pyridinebutane-1-ol;4-(4-Pyridinyl)butanol;4-Pyridinebutanol

Molecular Formula

C9H13NO

Molecular Weight

151.21

Smiles

C1=NC=CC(CCCCO)=C1

Boiling Point

290.9℃

Relative Density

1.03

pKa

15.09

General Description

4-Pyridinebutane-1-ol is a pyridine derivative featuring a four-carbon aliphatic chain (butane) connecting the pyridine ring at the C-4 position to a primary alcohol at the terminal end. The pyridine nitrogen is aromatic and can be protonated (to form a pyridinium salt) or quaternized (to form N-alkylpyridinium salts). The terminal primary alcohol can be oxidized, esterified, or converted to other functional groups.

Mechanism of Action

4-Pyridinebutane-1-ol functions as a bifunctional building block combining a heterocyclic pyridine pharmacophore with a flexible four-carbon linker terminating in a primary alcohol. The pyridine ring can coordinate to metal ions, act as a hydrogen bond acceptor, and participate in electrophilic substitution reactions. The primary alcohol is available for oxidation to the aldehyde or carboxylic acid, or for esterification. The flexible spacer reduces steric crowding around the pyridine ring.

Application

4-Pyridinebutane-1-ol is used as an intermediate in the synthesis of pyridine-containing pharmaceuticals including antihypertensives, vasodilators, and CNS agents. It is used in the synthesis of surfactants, corrosion inhibitors, and agricultural chemicals. In research chemistry, it serves as a precursor for the synthesis of N-alkylpyridinium salts, which are used as phase-transfer catalysts, ionic liquids, and antimicrobial agents.

What is the recommended storage condition for 4-Pyridinebutane-1-ol?

It should be stored at controlled room temperature in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Is a Certificate of Analysis (COA) available for 4-Pyridinebutane-1-ol?

Yes, a fully verified COA is issued for every batch and can be shared electronically. Additional documentation such as MSDS or impurity profiles may be requested separately.

What is the primary synthetic application of 4-Pyridinebutane-1-ol?

It is widely used as a key building block or intermediate in multi-step pharmaceutical synthesis workflows, providing versatile reactivity for constructing target molecular architectures.

Is 4-Pyridinebutane-1-ol compatible with common organic solvents used in pharmaceutical synthesis?

Solubility and compatibility information is available in the technical data sheet. For specific solvent compatibility questions, please contact our technical team.

Is 4-Pyridinebutane-1-ol manufactured under GMP conditions?

It is produced in facilities operating under applicable GMP or equivalent quality standards, ensuring consistent product quality and compliance with pharmaceutical industry requirements.