2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

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Cat Number

INT74901692

CAS Number

74901-69-2

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CAS Number

74901-69-2

Synonyms

7-dihydrothieno[3;tert-butyl 3-BroMo-6;2,4-Dichloro-6,7-dihydro-thieno[3,2-;2,4-dichloro-6H,7H-thieno[3,2-d]pyrimidine

Molecular Formula

C6H4Cl2N2S

Molecular Weight

207.08

Smiles

C1(Cl)=NC(Cl)=C2SCCC2=N1

Appearance

Off-white to light yellow solid

Boiling Point

329.4℃

Relative Density

1.613

General Description

2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine is a bicyclic heterocyclic building block featuring a fused thiophene and pyrimidine ring system. It carries two reactive chlorine atoms at the 2 and 4 positions, providing a highly versatile platform for synthesis. pyrimidine registration workflow]

Mechanism of Action

It serves as a dual-electrophilic scaffold. The chlorine atoms on the pyrimidine ring exhibit differential reactivity, allowing for sequential and regioselective substitution with various nucleophiles (such as amines or alcohols) to create libraries of bioactive thieno[3,2-d]pyrimidine derivatives.

Application

It is widely employed in medicinal chemistry for the synthesis of multi-target kinase inhibitors and other therapeutic agents targeting complex signal transduction pathways.