2-Methoxyethanamine

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Cat Number

INT109853

CAS Number

109-85-3

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Product Detail Description Customer Q&A

CAS Number

109-85-3

EINECS

203-712-1

Synonyms

1-Methoxy-2-aminoethane

Molecular Formula

C3H9NO

Molecular Weight

75.11

Smiles

COCCN

Appearance

Clear colorless to yellow liquid

Boiling Point

95℃

Relative Density

0.86

pKa

9.89

General Description

2-Methoxyethanamine (also known as 2-methoxyethylamine or MEA) is a simple ether-amine featuring an ethoxy fragment (O-CH3) attached to a two-carbon chain terminating in a primary amine. This small, bifunctional molecule combines the nucleophilicity of the primary amine with the ether linkage's polarity and metabolic stability, making it a versatile electrophile-neutral linker in pharmaceutical synthesis.

Mechanism of Action

2-Methoxyethanamine functions as a primary amine building block in pharmaceutical synthesis. The primary amine undergoes typical reactions including amide bond formation (with carboxylic acids or activated esters), sulfonamide formation, urea formation (with isocyanates), and reductive amination with aldehydes/ketones. The ether oxygen provides water solubility without the metabolic liability of acetal protecting groups, and the methoxy group is metabolically stable under most conditions.

Application

2-Methoxyethanamine is used as an intermediate in the synthesis of pharmaceuticals including local anesthetics (mepivacaine, ropivacaine), antihistamines, and beta-adrenergic blocking agents. It is used in the synthesis of dyes, pigments, corrosion inhibitors, and as a curing agent for epoxy resins. In agricultural chemistry, it serves as a building block for herbicides and plant growth regulators.

What is the recommended storage condition for 2-Methoxyethanamine?

It should be stored at controlled room temperature in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Is a Certificate of Analysis (COA) available for 2-Methoxyethanamine?

Yes, a fully verified COA is issued for every batch and can be shared electronically. Additional documentation such as MSDS or impurity profiles may be requested separately.

What is the primary synthetic application of 2-Methoxyethanamine?

It is widely used as a key building block or intermediate in multi-step pharmaceutical synthesis workflows, providing versatile reactivity for constructing target molecular architectures.

Is 2-Methoxyethanamine available in high-chemical-purity grade for pharmaceutical synthesis?

Yes, it is supplied in high chemical purity grades suitable for demanding pharmaceutical intermediate applications. Specifications and analytical data are available upon request.

What is the minimum order quantity (MOQ) for 2-Methoxyethanamine?

Flexible MOQ options are available to support both early-stage research and large-scale manufacturing needs. Our team can tailor order quantities to match your specific requirements.