2-chloro-9,10-dimethoxy-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one

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Cat Number

INT75535965

CAS Number

75535-96-5

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CAS Number

75535-96-5

Storage

2-8℃

Synonyms

2-Chloro-6,7-dihydro-9,10-dimethoxy-4H-pyrimido[6,1-a]isoquinolin-4-one

Molecular Formula

C14H13ClN2O3

Molecular Weight

292.72

Smiles

C12=CC(Cl)=NC(=O)N1CCC1=C2C=C(OC)C(OC)=C1

Appearance

Light yellow to yellow solid

Melting Point

235-236℃

Boiling Point

470.0℃

Relative Density

1.42

General Description

2-chloro-9,10-dimethoxy-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one is an advanced tricyclic heterocyclic derivative featuring a dihydropyrimido[6,1-a]isoquinoline core. It is substituted with a chlorine atom at the 2-position and two methoxy groups at the 9 and 10 positions, forming a rigid, planar aromatic system. isoquinolin-4-one registration workflow]

Mechanism of Action

It functions as a rigid heterocyclic template for drug development. The electron-rich methoxy groups and the electron-deficient pyrimido-isoquinoline core allow it to participate in specialized pi-stacking interactions and specific receptor binding, often influencing cellular signaling pathways.

Application

It is a critical intermediate for the synthesis of selective inhibitors targeting cyclic nucleotide phosphodiesterases (PDEs) and other pharmacological targets involved in cardiovascular health.