2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]acetonitrile

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Cat Number

INT1401031386

CAS Number

1401031-38-6

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Product Detail Description Customer Q&A

CAS Number

1401031-38-6

Storage

2-8℃

Synonyms

(R)-2-(9-(Pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl)acetonitrile;2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]acetonitril

Molecular Formula

C16H20N2O

Molecular Weight

256.34

Smiles

C1C2(C[C@@](C3=NC=CC=C3)(CC#N)CCO2)CCC1

Appearance

White to off-white solid

Melting Point

110 - 112℃

Boiling Point

445.3℃

Relative Density

1.13

pKa

5.41

General Description

2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]acetonitrile is a chiral primary amine featuring a pyridine ring attached to a spirocyclic oxaspirodecane system. It is a highly specialized pharmaceutical intermediate. dec-9-yl]ethanamine]

Mechanism of Action

It functions as a rigid heterocyclic building block. The (9R) configuration is critical for the precise positioning of the amine and pyridine groups, which is required for high-affinity binding to target receptors.

Application

It is a critical intermediate in the final synthesis of Oliceridine and related selective opioid receptor modulators.