17α-Methyl-3-ethoxypregna-3,5-dien-20-one

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Cat Number

INT902768494

CAS Number

902768-49-4

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Product Detail Description Customer Q&A

CAS Number

902768-49-4

Synonyms

Medrogestone Intermediate;Pregna-3,5-dien-20-one, 3-ethoxy-17-methyl-

Molecular Formula

C24H36O2

Molecular Weight

356.54

General Description

17α-Methyl-3-ethoxypregna-3,5-dien-20-one is a steroid derivative featuring a methyl substituent at the C-17α position, an ethoxy group at C-3, and a diene system (pregna-3,5-diene) with a ketone at C-20. This is a highly modified steroidal intermediate with multiple points of structural elaboration relative to the parent steroid nucleus. The 17α-methyl and 3-ethoxy modifications confer enhanced oral bioavailability and altered pharmacokinetics compared to natural steroids.

Mechanism of Action

17α-Methyl-3-ethoxypregna-3,5-dien-20-one functions as a steroid intermediate in the synthesis of modified anabolic steroids, oral contraceptives, and anti-inflammatory steroids. The 17α-methyl group blocks 17-hydroxylation, extending the steroid half-life by preventing its degradation via the CYP17 pathway. The 3-ethoxy group (an enol ether) is hydrolyzed in vivo to the 3-ketone, the active form. The 3,5-diene (conjugated diene) system contributes to UV absorption and photochemical reactivity.

Application

17α-Methyl-3-ethoxypregna-3,5-dien-20-one is used as an intermediate in the synthesis of anabolic steroids (nandrolone and oxandrolone derivatives), oral progestins, and corticosteroids. The steroid scaffold is foundational to many hormonal therapeutics targeting androgen, estrogen, progestin, glucocorticoid, and mineralocorticoid receptors. It is also used in the synthesis of bile acid derivatives and steroidal sensors.

What is the recommended storage condition for 17α-Methyl-3-ethoxypregna-3,5-dien-20-one?

It should be stored at controlled room temperature in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Can we obtain batch-specific analytical data for 17α-Methyl-3-ethoxypregna-3,5-dien-20-one?

Batch-specific COA documents are standard with every shipment. Additional analytical reports, including HPLC chromatograms or spectral data, may be provided upon request.

Is 17α-Methyl-3-ethoxypregna-3,5-dien-20-one compatible with common organic solvents used in pharmaceutical synthesis?

Solubility and compatibility information is available in the technical data sheet. For specific solvent compatibility questions, please contact our technical team.

Can 17α-Methyl-3-ethoxypregna-3,5-dien-20-one be provided with custom specifications for synthetic applications?

Custom specifications including adjusted particle size, solvent residue limits, or additional purity testing can be arranged for qualified customers with defined requirements.

Is 17α-Methyl-3-ethoxypregna-3,5-dien-20-one manufactured under GMP conditions?

It is produced in facilities operating under applicable GMP or equivalent quality standards, ensuring consistent product quality and compliance with pharmaceutical industry requirements.