15-hydroxy Lubiprostone

Inquiry

Cat Number

API475992304

CAS Number

475992-30-4

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Product Detail

CAS Number

475992-30-4

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Description

15-hydroxy Lubiprostone, synthesized through cyclooxygenase-mediated metabolism of dihomo-γ-linolenic acid (DGLA), functions by inhibiting platelet aggregation (IC50= 40 nM) and enhancing vasodilation. Its analog, 13,14-dihydro-16,16-difluoro PGE1, and the metabolite, 13,14-dihydro PGE1, both retain similar anti-aggregatory properties to the original compound. The inclusion of two electron-withdrawing fluorine atoms in 13,14-dihydro-16,16-difluoro PGE1 is believed to increase molecular stability and potentially extend bioavailability by resisting hydrolytic degradation.

Molecular Formula

C20H34F2O5

Molecular Weight

392.484

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