13C/14C Breath Test for Helicobacter pylori Diagnostics

About Helicobacter pylori

Helicobacter pylori (Hp) is a Gram-negative bacterium that can colonize the human gastric mucosa and produce substances such as urease to neutralize gastric acid, thereby surviving in a highly acidic environment and causing persistent infection. According to statistics, about 50% of the global population is infected with Hp, and the infection rate shows significant regional differences, with some areas having an infection rate as high as 80%. Socioeconomic status, hygiene conditions, and education levels are key factors influencing the Hp infection rate.

Hp infection is closely related to various digestive system diseases, such as chronic gastritis, peptic ulcers, gastric malignancies, gastric mucosa-associated lymphoid tissue (MALT) lymphoma and functional dyspepsia. Some studies have shown that Hp may also be associated with excetrio-gastrointestinal diseases such as iron deficiency anemia and idiopathic thrombocytopenic purpura.

Helicobacter pylori Detection

Current detection methods for Hp include invasive endoscopic examination and non-invasive methods. Non-invasive methods include the Urea Breath Test (UBT), serological testing and fecal antigen testing. Among them, UBT is a specific detection method based on the urease activity of Hp, which is simple to operate and has high acceptance among subjects, and has become a commonly used clinical method for diagnosing Hp infection and evaluating treatment efficacy.

The principle of UBT is to detect the gas exhaled by the subject, which contains 13C or 14C labeled CO2 produced by the decomposition of urea by Hp in the stomach, to obtain the result of Hp infection.

Clinical Significance of Helicobacter pylori Testing

• Achieving an early diagnosis
• Contributing to gastric cancer prevention
• Reducing ulcer recurrence rate
• Alleviating symptoms in some patients with digestive disorders
• Lower the infection rate in the population

Urea 13C/14C Breath Test Products

Protheragen deeply understands the critical role of Hp testing in the prevention and treatment of digestive system diseases. We provide leading urea 13C/14C breath test solutions for testing institutions, hospitals, health check centers and research units. Our products are designed to offer better solutions for the diagnosis, treatment and prevention of Hp infections worldwide.

Urea 14C Breath Test Product Features

• High sensitivity: It can detect extremely low-level infections, ensuring accurate results.
• Cost-effectiveness: The procedure uses relatively simple and low-cost equipment.
• Convenience: It features a short testing time and a simple operational procedure.
• Trace radioactivity: It involves only trace levels of radioactivity, ensuring patient safety.

Urea 13C Breath Test Product Features

13C is a stable isotope, which has unique advantages over 14C:

• Absolute safety: non-radioactive, suitable for all populations, including pregnant women and children
• High accuracy and reliability
• Good repeatability

Our products are characterized by ease of use, non-invasive and painless operation, high sensitivity, high safety and no risk of cross-infection. In addition to providing urea marking reagents, we have a rich reserve of 14C intermediates and are committed to supporting human health detection tools and drug research and development.

With outstanding product quality, comprehensive system support, continuous technological innovation and flexible scenario adaptation, our urea 13C/14C breath test series products have become trusted Hp diagnostic tools in the industry. If you are interested in our products, please contact us.