1,3-Butadiene diepoxide

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Cat Number

INT1464535

CAS Number

1464-53-5

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Product Detail Description Customer Q&A

CAS Number

1464-53-5

EINECS

215-979-1

Storage

2-8℃

Synonyms

2,4-diepoxybutane;3,4-Diepoxybutane

Molecular Formula

C4H6O2

Molecular Weight

86.09

Smiles

C1OC1C2CO2

Appearance

Liquid

Melting Point

3℃

Boiling Point

56-58℃

Relative Density

1.1

General Description

1,3-Butadiene diepoxide (also known as 1,2:3,4-diepoxybutane) is a bifunctional epoxide featuring two epoxide rings at the terminal positions of a four-carbon chain. The presence of two electrophilic epoxide groups on the same molecule makes it a potent cross-linking agent and alkylating agent capable of forming covalent adducts with nucleophilic sites on biomolecules. It is the simplest polyepoxide cross-linker.

Mechanism of Action

1,3-Butadiene diepoxide acts as a bifunctional alkylating agent and cross-linker. Each epoxide ring undergoes acid-catalyzed or base-catalyzed ring opening by nucleophiles (amines, thiols, carboxylates, hydroxyl groups) under physiological conditions, forming covalent bonds. In biological systems, it cross-links complementary strands of DNA (interstrand cross-link) and reacts with nucleophilic amino acid residues in proteins. This bifunctional alkylation is the basis of its cytotoxic and anticancer activity.

Application

1,3-Butadiene diepoxide is used as a cross-linking agent in polymer chemistry (epoxy resins, cross-linked polyethers) and as a reactive intermediate in organic synthesis for introducing 1,2-diol units via epoxide ring-opening. It has also been investigated as an anticancer alkylating agent.

What is the recommended storage condition for 1,3-Butadiene diepoxide?

It should be stored at 2-8°C in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

What documentation is provided with each batch of 1,3-Butadiene diepoxide?

Each batch is accompanied by a Certificate of Analysis (COA) covering identity, potency, and relevant purity tests. Safety Data Sheets (SDS) are available upon request.

What analytical characterization data is available for 1,3-Butadiene diepoxide?

Standard analytical data including HPLC purity profile, NMR confirmation, and physical specifications are included in the COA. Additional characterization data can be arranged upon request.

Is 1,3-Butadiene diepoxide available in high-chemical-purity grade for pharmaceutical synthesis?

Yes, it is supplied in high chemical purity grades suitable for demanding pharmaceutical intermediate applications. Specifications and analytical data are available upon request.

What is the minimum order quantity (MOQ) for 1,3-Butadiene diepoxide?

Flexible MOQ options are available to support both early-stage research and large-scale manufacturing needs. Our team can tailor order quantities to match your specific requirements.