10-Hydroxycamptothecin

Inquiry

Cat Number

PIPE-0601

CAS Number

19685-09-7

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Product Detail

CAS Number

19685-09-7

EINECS

805-668-4

Storage

Room temperature

Synonyms

(S)-10-Hydroxycamptothecin Hydroxycamptothecin 10-hydroxycamptothecine

Description

10-Hydroxycamptothecin inhibits the growth of BT-20 and MDA-231 cell with IC50 of 34.3 nM and 7.27 nM, respectively, more potently than camptothecin (CPT) with IC50 of >500 nM. 10-Hydroxycamptothecin is also an impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer.

Molecular Formula

C20H16N2O5

Molecular Weight

364.4

Appearance

Light Yellow to Yellow Solid

Melting Point

268-270℃

Boiling Point

820.7±65.0℃ at 760 mmHg

Purity

HPLC≥98%