1-Oxa-6-aza-spiro[2.5]octan-6-carboxylic acid tert-butyl ester

Inquiry

Cat Number

INT147804306

CAS Number

147804-30-6

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Product Detail Description Customer Q&A

CAS Number

147804-30-6

EINECS

687-899-9

Storage

Room temperature

Synonyms

1-Oxa-6-aza-spiro[2.5]octan-6-carboxylic acid tert-butyl ester;6-Aza-1-oxaspiro[2.5]octane-6-carboxylic acid tert-butyl ester

Molecular Formula

C11H19NO3

Molecular Weight

213.27

Smiles

O1C2(CCN(C(OC(C)(C)C)=O)CC2)C1

Appearance

White powder

Melting Point

50-52℃

Boiling Point

298℃

Relative Density

1.12

General Description

1-Oxa-6-aza-spiro[2.5]octan-6-carboxylic acid tert-butyl ester features a spiro-fused bicyclic scaffold combining an oxetane ring and a piperidine ring at a common spiro carbon. The nitrogen of the piperidine is protected as a Boc carbamate. This spiro-oxetane-piperidine architecture is a privileged structural motif in medicinal chemistry.

Mechanism of Action

1-Oxa-6-aza-spiro[2.5]octan-6-carboxylic acid tert-butyl ester functions as a spirocyclic building block. The spiro[2.5]octane (oxetane + spiro carbon) moiety introduces three-dimensionality and steric bulk that improves target selectivity. The oxetane ring is metabolically stable and contributes moderate polarity. The N-Boc carbamate protects the piperidine nitrogen during cross-coupling and other reactions.

Application

1-Oxa-6-aza-spiro[2.5]octan-6-carboxylic acid tert-butyl ester is used as an intermediate in the synthesis of spirocyclic pharmaceuticals targeting neurological disorders (especially NMDA receptor modulators), and in the synthesis of spirocyclic peptidomimetics. The spiro-oxetane motif is a proven privileged structure in GPCR and kinase inhibitor programs.

What is the recommended storage condition for 1-Oxa-6-aza-spiro[2.5]octan-6-carboxylic acid tert-butyl ester?

It should be stored at controlled room temperature in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Can we obtain batch-specific analytical data for 1-Oxa-6-aza-spiro[2.5]octan-6-carboxylic acid tert-butyl ester?

Batch-specific COA documents are standard with every shipment. Additional analytical reports, including HPLC chromatograms or spectral data, may be provided upon request.

Is 1-Oxa-6-aza-spiro[2.5]octan-6-carboxylic acid tert-butyl ester available in high-chemical-purity grade for pharmaceutical synthesis?

Yes, it is supplied in high chemical purity grades suitable for demanding pharmaceutical intermediate applications. Specifications and analytical data are available upon request.

Can 1-Oxa-6-aza-spiro[2.5]octan-6-carboxylic acid tert-butyl ester be provided with custom specifications for synthetic applications?

Custom specifications including adjusted particle size, solvent residue limits, or additional purity testing can be arranged for qualified customers with defined requirements.

What quality standards govern the production of 1-Oxa-6-aza-spiro[2.5]octan-6-carboxylic acid tert-butyl ester?

Production is carried out under GMP-aligned quality systems with full traceability and documented quality controls for each manufacturing run.