1-Ethyl-4-(4-piperidyl)piperazine Hydrochloride

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Cat Number

INT1181457793

CAS Number

1181457-79-3

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Product Detail Description Customer Q&A

CAS Number

1181457-79-3

Storage

2-8℃

Synonyms

Piperazine, 1-ethyl-4-(4-piperidinyl)-, hydrochloride

Molecular Formula

C11H24ClN3

Molecular Weight

233.78

Appearance

Off-white powder

General Description

1-Ethyl-4-(4-piperidyl)piperazine Hydrochloride is a bis-piperazine compound (also described as N-ethylpiperazine substituted at the C-4 position with a 4-piperidyl group) formulated as the hydrochloride salt. This structure creates a flexible molecular backbone containing two piperazine rings connected through a carbon-carbon bond, providing multiple basic nitrogen atoms (three in total) for salt formation, metal coordination, and hydrogen bonding with biological targets.

Mechanism of Action

1-Ethyl-4-(4-piperidyl)piperazine Hydrochloride functions as a flexible piperazine-rich building block in pharmaceutical synthesis. The three basic nitrogen atoms (one in each piperazine ring plus the ring nitrogen of the piperidine substituent) provide multiple protonation states and binding modes. The flexible ethylene and piperidyl linkers allow the molecule to adopt multiple conformations, making it suitable for targeting proteins with diverse binding pocket geometries.

Application

1-Ethyl-4-(4-piperidyl)piperazine Hydrochloride is used as an intermediate in the synthesis of multi-targeting CNS agents, H1 antihistamines, and 5-HT receptor modulators. The bis-piperazine scaffold is found in several clinically used drugs including certain antipsychotics (pipamperone), anxiolytics, and antiemetics. It is also used as a precursor for the synthesis of chelating agents and in the preparation of polymeric materials.

What is the recommended storage condition for 1-Ethyl-4-(4-piperidyl)piperazine Hydrochloride?

It should be stored at 2-8°C in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Is a Certificate of Analysis (COA) available for 1-Ethyl-4-(4-piperidyl)piperazine Hydrochloride?

Yes, a fully verified COA is issued for every batch and can be shared electronically. Additional documentation such as MSDS or impurity profiles may be requested separately.

Can 1-Ethyl-4-(4-piperidyl)piperazine Hydrochloride be provided with custom specifications for synthetic applications?

Custom specifications including adjusted particle size, solvent residue limits, or additional purity testing can be arranged for qualified customers with defined requirements.

What analytical characterization data is available for 1-Ethyl-4-(4-piperidyl)piperazine Hydrochloride?

Standard analytical data including HPLC purity profile, NMR confirmation, and physical specifications are included in the COA. Additional characterization data can be arranged upon request.

Is 1-Ethyl-4-(4-piperidyl)piperazine Hydrochloride suitable for use in regulated pharmaceutical processes?

Yes, it is manufactured under quality standards consistent with regulated pharmaceutical applications, including in-process controls and release testing aligned with industry requirements.