1-Aminocyclobutanecarboxylic acid

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Cat Number

INT22264502

CAS Number

22264-50-2

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Product Detail Description Customer Q&A

CAS Number

22264-50-2

Storage

Keep in dark place, inert atmosphere, room temperature

Synonyms

1-Aminocyclobutaneca;1-Amino-1-carboxycyclobutane

Molecular Formula

C5H9NO2

Molecular Weight

115.13

Smiles

C1(N)(C(O)=O)CCC1

Appearance

White powder

Melting Point

261℃

Boiling Point

241.1℃

Relative Density

1.29

pKa

2.38

General Description

1-Aminocyclobutanecarboxylic acid is a cyclic amino acid derivative, often referred to as a constrained amino acid mimic. It features an amino group and a carboxylic acid group attached to the same carbon of a cyclobutane ring.

Mechanism of Action

It serves as a conformational constraint in peptidomimetic synthesis. By incorporating this rigid cyclic core into a peptide chain, it restricts the conformational space of the molecule, enhancing binding affinity and metabolic stability.

Application

It is a vital building block for the synthesis of novel enzyme inhibitors, neurotransmitter analogs, and advanced pharmaceutical peptidomimetics.