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Cat Number: API1365267271

X-376Ensartinib, X-396

CAS Number

1365267-27-1

Description

X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins, and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development.

Molecular Formula

C25H25Cl2FN6O3

Molecular Weight

547.41

Smiles

C[C@@H](OC1CC(NNC1N)C(=O)NC1CCC(CC1)C(=O)N1CCN(C)CC1)C1C(Cl)CCC(F)C1Cl

Purity

0.9872

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 37 mg/mL (67.59 mM)