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Cat Number: API1207456016

TalazoparibLT-673, BMN-673

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CAS Number

1207456-01-6

Description

Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).

Molecular Formula

C19H14F2N6O

Molecular Weight

380.35

Smiles

CN1NCNC1[C@@H]1[C@H](NC2CC(F)CC3C2C1N[NH]C3=O)C1CCC(F)CC1

Purity

0.9985

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 36 mg/mL (94.6 mM)H2O: < 1 mg/mL (insoluble or slightly soluble)Ethanol: < 1 mg/mL (insoluble or slightly soluble)10% DMSO+90% Saline: 0.1 mg/mL (0.26 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.

Relative Density

1.63

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