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Cat Number: API557795194

SunitinibSU 11248

CAS Number

557795-19-4

Description

Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM). It exhibits antitumor activity and is used for treating kidney cancer and gastrointestinal tumors.

Molecular Formula

C22H27FN4O2

Molecular Weight

398.47

Smiles

C(=C\1/C=2C(NC1=O)=CC=C(F)C2)\C3=C(C)C(C(NCCN(CC)CC)=O)=C(C)N3

Purity

0.9967

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 25 mg/mL (62.74 mM)10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1.25 mg/mL (3.14 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.H2O: < 1 mg/mL (insoluble or slightly soluble)Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Relative Density

1.229

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