An ISO9001 Certified Supplier of Pharmaceutical Ingredients and Specialty Chemicals

Cat Number: API38194502

SulindacClinoril, MK-231, Sulindac sulfoxide, Arthrocine

CAS Number

38194-50-2

Description

Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death.

Molecular Formula

C20H17FO3S

Molecular Weight

356.41

Smiles

C(=C/1\C=2C(C(CC(O)=O)=C1C)=CC(F)=CC2)\C3=CC=C(S(C)=O)C=C3

Purity

0.9949

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

Ethanol: 9 mg/mL (25.25 mM)DMSO: 50 mg/mL (140.29 mM)