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Cat Number: API49627272

Sulindac sulfidecis-Sulindac sulfide

CAS Number

49627-27-2

Description

Sulindac sulfide (cis-Sulindac sulfide) is a non-steroidal anti-inflammatory compound that has a high affinity for COX-1 and acts as an inhibitor in Ras activation of Raf-1. Sulindac sulfide is a non-competitive inhibitor of gamma-secretase with an IC50 value of 20.2 μM. It is an active metabolite of sulinic acid.

Molecular Formula

C20H17FO2S

Molecular Weight

340.41

Smiles

C(=C/1\C=2C(C(CC(O)=O)=C1C)=CC(F)=CC2)\C3=CC=C(SC)C=C3

Purity

0.9968

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 45 mg/mL (132.19 mM), Sonication is recommended.