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Cat Number: API2296729003

SotorasibAMG-510

CAS Number

2296729-00-3

Description

Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib exhibits inhibitory activity against KRAS G12C mutant tumors.

Molecular Formula

C30H30F2N6O3

Molecular Weight

560.59

Smiles

CC(C)C1NCCC(C)C1-N1C2NC(C(F)CC2C(NC1=O)N1CCN(C[C@@H]1C)C(=O)C=C)-C1C(O)CCCC1F

Purity

0.9989

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

H2O: 33.33 mg/mL (59.46 mM), when pH is adjusted to 11 with NaOH. Sonication is recommended.DMSO: 60 mg/mL (107.03 mM), Sonication is recommended.