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Cat Number: API284461730

SorafenibBay 43-9006

CAS Number

284461-73-0

Description

Sorafenib (Bay 43-9006) is a multikinase inhibitor that targets Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. It exhibits antitumor properties and can induce autophagy, apoptosis, and agonistic iron death.

Molecular Formula

C21H16ClF3N4O3

Molecular Weight

464.82

Smiles

O(C=1C=C(C(NC)=O)N=CC1)C2=CC=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2

Purity

0.9989

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.9 mg/mL (12.69 mM), In vivo: Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.DMF: 3.33 mg/mL (7.17 mM）DMSO: 55 mg/mL (118.33 mM)Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Relative Density

1.455. Temperature:20.

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