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Cat Number: API475207591

Sorafenib tosylateBay 43-9006

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CAS Number

475207-59-1

Description

Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).

Molecular Formula

C21H16ClF3N4O3·C7H8O3S

Molecular Weight

637.03

Smiles

CC1CCC(CC1)S(O)(=O)=O.CNC(=O)C1CC(OC2CCC(NC(=O)NC3CCC(Cl)C(C3)C(F)(F)F)CC2)CCN1

Purity

0.9981

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 200 mg/mL (313.96 mM), Sonication is recommended.Ethanol: < 1 mg/mL (insoluble or slightly soluble)H2O: < 1 mg/mL (insoluble or slightly soluble)10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (7.85 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.

Relative Density

1.454

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