Cat Number: API606143526

SelumetinibAZD6244, ARRY-142886

APIs
CAS Number
606143-52-6
Description
Selumetinib (AZD6244) is a MEK1/2 inhibitor that inhibits MEK1 (IC50=14 nM) with potent selectivity and is non-ATP-competitive. Selumetinib has antitumor activity and is used for the treatment of neurofibromatosis type 1 (NF1).
Molecular Formula
C17H15BrClFN4O3
Molecular Weight
457.68
Smiles
CN1C=NC2=C(F)C(NC3=CC=C(Br)C=C3Cl)=C(C=C12)C(=O)NOCCO
Purity
0.9946
Storage
Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.
Solubility Information
DMSO: 1 mg/mL, Sonication is recommended.Ethanol: < 1 mg/mL (insoluble or slightly soluble)H2O: < 1 mg/mL (insoluble or slightly soluble)
Relative Density
1.69
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