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Cat Number: API1393477729

Selinexor (KPT-330)Selinexor, KPT-330

CAS Number

1393477-72-9

Description

Selinexor (KPT-330) is a small molecule inhibitor of CRM1 with selective and oral activity. Selinexor blocks the cell cycle, induces apoptosis, and has antitumor activity for the treatment of multiple myeloma.

Molecular Formula

C17H11F6N7O

Molecular Weight

443.31

Smiles

FC(F)(F)C1CC(CC(C1)C(F)(F)F)-C1NCN(\C=C/C(=O)NNC2CNCCN2)N1

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 8.2 mg/mL (18.5 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.H2O: < 1 mg/mL (insoluble or slightly soluble)Ethanol: 38 mg/mL (85.7 mM)DMSO: 55 mg/mL (124.07 mM)

Relative Density

1.55 (Predicted)

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