An ISO9001 Certified Supplier of Pharmaceutical Ingredients and Specialty Chemicals

Cat Number: API439081182

(S)-AfatinibBIBW2992

CAS Number

439081-18-2

Description

(S)-Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, EGFR (L858R), EGFR (L858R/T790M), HER2, and HER4, respectively.

Molecular Formula

C24H25ClFN5O3

Molecular Weight

485.94

Smiles

CN(C)CC=CC(=O)NC1CC2C(NC3CCC(F)C(Cl)C3)NCNC2CC1O[C@H]1CCOC1

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)DMSO: 90 mg/mL (185.2 mM)Ethanol: 12 mg/mL (24.7 mM)10% DMSO+40% PEG300+5% Tween 80+45% Saline: 9 mg/mL (18.52 mM), In vivo: Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.

Relative Density

1.38

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

INFORMATION

Tel:
E-mail:
Address:
WhatsAPP

Member of

CERTIFICATION