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Cat Number: API552292087

RolapitantSCH619734

CAS Number

552292-08-7

Description

Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP).

Molecular Formula

C25H26F6N2O2

Molecular Weight

500.48

Smiles

[H][C@](C)(OC[C@]1(CC[C@]2(CCC(=O)N2)CN1)C1CCCCC1)C1CC(CC(C1)C(F)(F)F)C(F)(F)F

Purity

0.9834

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 55 mg/mL (109.89 mM), Sonication is recommended.