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Cat Number: API858102791

Rolapitant hydrochlorideRolapitant HCl

CAS Number

858102-79-1

Description

Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting, and orally active neurokinin 1 (NK1) receptor antagonist with a K_i of 0.66 nM, which does not interact with CYP3A4 and demonstrates potent centrally-mediated anti-emetic activity in both acute and delayed ferret emesis models.

Molecular Formula

C25H27ClF6N2O2

Molecular Weight

536.94

Smiles

Cl.C[C@@H](OC[C@]1(CC[C@]2(CCC(=O)N2)CN1)C1CCCCC1)C1CC(CC(C1)C(F)(F)F)C(F)(F)F

Purity

0.9979

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 50 mg/mL (93.12 mM)