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Cat Number: API755037037

RegorafenibBAY 73-4506, Fluoro-Sorafenib

CAS Number

755037-03-7

Description

Regorafenib (BAY 73-4506) is an orally active, multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ, exhibiting both antitumor and anti-angiogenic activity.

Molecular Formula

C21H15ClF4N4O3

Molecular Weight

482.82

Smiles

CNC(=O)C1CC(OC2CCC(NC(=O)NC3CCC(Cl)C(C3)C(F)(F)F)C(F)C2)CCN1

Purity

0.9995

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 60 mg/mL (124.27 mM)10% DMSO+40% PEG300+5% Tween 80+45% Saline: 9 mg/mL (18.64 mM), In vivo: Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.Ethanol: < 1 mg/mL (insoluble or slightly soluble)H2O: < 1 mg/mL (insoluble or slightly soluble)

Relative Density

1.491

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