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Cat Number: API834153876

(R)-ElagolixNBI-56418

CAS Number

834153-87-6

Description

(R)-Elagolix (NBI-56418) is a short-acting, nonpeptide, GnRH antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively. administered orally, that unlike injectable depot GnRH agonists and antagonists, produces a dose-dependent suppression of ovarian estrogen production, that is, from partial suppression at lower doses to full suppression at higher doses.

Molecular Formula

C32H30F5N3O5

Molecular Weight

631.59

Smiles

[H][C@@](CN1C(=O)C(C(C)N(CC2C(F)CCCC2C(F)(F)F)C1=O)-C1CCCC(OC)C1F)(NCCCC(O)=O)C1CCCCC1

Purity

0.9763

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 100 mg/mL (158.33 mM)