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Cat Number: API943319708

PonatinibAP24534

CAS Number

943319-70-8

Description

Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor with IC50 values of 0.37 nM (Abl), 1.1 nM (PDGFRα), 1.5 nM (VEGFR2), 2.2 nM (FGFR1), and 5.4 nM (Src).

Molecular Formula

C29H27F3N6O

Molecular Weight

532.56

Smiles

C(#CC1=CC(C(NC2=CC(C(F)(F)F)=C(CN3CCN(C)CC3)C=C2)=O)=CC=C1C)C=4N5C(=NC4)C=CC=N5

Purity

0.9974

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

Ethanol: 26.6 mg/mL (50 mM)DMSO: 16.67 mg/mL (31.3 mM)10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.33 mg/mL (10.01 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.

Relative Density

1.292

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