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Cat Number: API1029044163

PexidartinibPLX-3397

CAS Number

1029044-16-3

Description

Pexidartinib (PLX-3397) is a capsule containing a small-molecule receptor tyrosine kinase (RTK) inhibitor targeting KIT, CSF1R, and FLT3, with potential antineoplastic activity.

Molecular Formula

C20H15ClF3N5

Molecular Weight

417.81

Smiles

FC(F)(F)C1CCC(CNC2CCC(CC3C[NH]C4NCC(Cl)CC34)CN2)CN1

Purity

0.9966

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 7.7 mg/mL (18.43 mM), In vivo: Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.DMSO: 45 mg/mL (107.7 mM)Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Relative Density

1.458 (Predicted)

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