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Cat Number: API1513857776

PemigatinibINCB054828

CAS Number

1513857-77-6

Description

Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR, with IC50 values of 0.4 nM for FGFR1, 0.5 nM for FGFR2, 1.2 nM for FGFR3, and 30 nM for FGFR4.

Molecular Formula

C24H27F2N5O4

Molecular Weight

487.5

Smiles

CCN1C(=O)N(CC2C[NH]C3NC(CN4CCOCC4)CC3C12)C1C(F)C(OC)CC(OC)C1F

Purity

0.9995

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 4.88 mg/mL (10 mM), Sonication is recommended.10% DMSO+90% Saline: 0.1 mg/mL (0.21 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.

Relative Density

1.44 (Predicted)

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