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Cat Number: API763113220

OlaparibAZD2281, KU0059436

CAS Number

763113-22-0

Description

Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is selective and orally active. Olaparib exhibits autophagy and mitochondrial autophagy activation activity.

Molecular Formula

C24H23FN4O3

Molecular Weight

434.46

Smiles

C(C=1C=2C(C(=O)NN1)=CC=CC2)C3=CC(C(=O)N4CCN(C(=O)C5CC5)CC4)=C(F)C=C3

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)DMSO: 50 mg/mL (115.09 mM)Ethanol: < 1 mg/mL (insoluble or slightly soluble)10% DMSO+40% PEG300+5% Tween 80+45% Saline: 8 mg/mL (18.41 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.

Relative Density

1.43

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