An ISO9001 Certified Supplier of Pharmaceutical Ingredients and Specialty Chemicals

Cat Number: API231277922

LapatinibGSK572016, GW572016

CAS Number

231277-92-2

Description

Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity. Lapatinib has antitumor activity and can be used to treat advanced or metastatic breast cancer with HER2 overexpression.

Molecular Formula

C29H26ClFN4O4S

Molecular Weight

581.06

Smiles

N(C=1C2=C(C=CC(=C2)C=3OC(CNCCS(C)(=O)=O)=CC3)N=CN1)C4=CC(Cl)=C(OCC5=CC(F)=CC=C5)C=C4

Purity

0.9989

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 50 mg/mL (86.05 mM), Sonication is recommended.H2O: < 1 mg/mL (insoluble or slightly soluble)10% DMSO+40% PEG300+5% Tween 80+45% Saline: 9.3 mg/mL (16.01 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Relative Density

1.381 (Predicted)

HOURS

Daily: 9.30 AM–6.00 PM
Sunday : 9.30 AM–1.00 PM
Holidays: Closed

INFORMATION

Tel:
E-mail:
Address:
WhatsAPP

Member of

CERTIFICATION