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Cat Number: API388082788

Lapatinib ditosylate monohydrateLapatinib ditoluenesulfonate monohydrate, Tyverb ditosylate monohydrate, Lapatinib ditosylate monohydrate, Lapatinib ditosilate hydrate, Tykerb ditosylate monohydrate

CAS Number

388082-78-8

Description

Lapatinib ditosylate (Lapatinib tosilate) monohydrate is a tyrosine kinase receptor inhibitor used in the therapy of advanced breast cancer and other solid tumors. Lapatinib ditosylate monohydrate therapy is associated with transient elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury.

Molecular Formula

C29H26ClFN4O4S·2(C7H8O3S)·H2O

Molecular Weight

943.47

Smiles

N1CNC(C2CC(CCC12)C1OC(CC1)CNCCS(=O)(=O)C)NC1CC(C(CC1)OCC1CC(CCC1)F)Cl.C1(CCC(CC1)C)S(=O)(=O)O.O.C1(CCC(CC1)C)S(=O)(=O)O

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 91 mg/mL (96.5 mM)

Relative Density