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Cat Number: API184475352

GefitinibZD1839

CAS Number

184475-35-2

Description

Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell lung cancers. Gefitinib administration RESULTS in the development of the EGFR C797S resistance mutation.

Molecular Formula

C22H24ClFN4O3

Molecular Weight

446.9

Smiles

N(C=1C2=C(C=C(OC)C(OCCCN3CCOCC3)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

Purity

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 18.33 mg/mL (41.02 mM)Ethanol: 4.5 mg/mL (10 mM)10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4.47 mg/mL (10 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.

Relative Density

1.322

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